Encodes the Arabidopsis homolog of MSH4, a meiosis-specific member of the MutS-homolog family of genes. It is expressed only in floral tissues and only during early meiotic prophase I, preceding the synapsis of homologous chromosomes. It is involved in the early steps of recombination.
Computational Description
MUTS-like protein 4 (MSH4); FUNCTIONS IN: damaged DNA binding, mismatched DNA binding, ATP binding; INVOLVED IN: mismatch repair, synapsis, meiotic prophase I; LOCATED IN: condensed nuclear chromosome; EXPRESSED IN: flower, sporocyte; EXPRESSED DURING: petal differentiation and expansion stage, IL.00 inflorescence just visible; CONTAINS InterPro DOMAIN/s: DNA mismatch repair protein MutS, clamp (InterPro:IPR007861), DNA mismatch repair protein MutS, C-terminal (InterPro:IPR000432), DNA mismatch repair protein MutS, core (InterPro:IPR007696); BEST Arabidopsis thaliana protein match is: MUTS homolog 2 (TAIR:AT3G18524.1); Has 13303 Blast hits to 13154 proteins in 2712 species: Archae - 169; Bacteria - 9120; Metazoa - 661; Fungi - 837; Plants - 451; Viruses - 3; Other Eukaryotes - 2062 (source: NCBI BLink).